Factsheets

In vitro Metabolism

Metabolic Stability

• Metabolic stability factsheet Admescope
• Low clearance metabolism factsheet Admescope

Metabolite Identification and Profiling

• Metabolite identification in vivo factsheet Admescope
• Peptide metabolite identification factsheet Admescope

Enzyme Reaction Phenotyping

• CYP phenotyping factsheet Admescope
• Low clearance CYP phenotyping factsheet Admescope
• UGT phenotyping factsheet Admescope

Reactive Metabolite Screening

• Reactive metabolites factsheet Admescope
• Covalent binding of reactive metabolites factsheet Admescope

Acyl-Glucuronide Reactivity

• Acyl glucuronide reactivity factsheet Admescope

Safety Metabolism

• MIST analysis factsheet Admescope
• Radiolabeled in vivo metabolite ID and profiling factsheet Admescope

In vivo DMPK

• In vivo PK factsheet Admescope
• Metabolite identification in vivo factsheet Admescope

Drug Interactions

CYP Inhibition

• CYP inhibition factsheet Admescope
• CYP inhibition screening factsheet Admescope
• CYP inhibition kinetics factsheet Admescope

UGT Inhibition

• UGT inhibition factsheet Admescope

CYP Induction

• CYP induction factsheet Admescope
• CYP induction screening factsheet Admescope
• UGT induction factsheet Admescope

UGT Induction

• UGT induction factsheet Admescope

Permeability and Transporters

Caco-2 Permeability

• Caco-2 permeability factsheet Admescope
• Caco-2 permeability screening factsheet Admescope

BCS Classification Caco-2 Permeability

• BCS classification Caco-2 factsheet Admescope

Efflux Transporters

• Efflux transporter inhibition vesicle factsheet Admescope
• Efflux transporter inhibition cell monolayer factsheet Admescope
• Efflux transporter substrate factsheet Admescope

Uptake Transporters

• Uptake transporter inhibition factsheet Admescope
• Uptake transporter substrate factsheet Admescope

Physicochemistry and Binding

Solubility

• Solubility factsheet Admescope

Lipophilicity (logP/D)

• LogD factsheet Admescope
• eLogD factsheet Admescope

Plasma Protein Binding

• Protein binding RED factsheet Admescope
• Protein binding UF factsheet Admescope

Blood to Plasma Ratio

• Blood to plasma ratio factsheet Admescope

In vitro Toxicology

Hepatotoxicity Screening

• Steatosis and phospholipidosis factsheet Admescope

Genotoxicity Screening

• Ames screening factsheet Admescope
• MNT screening factsheet Admescope

Cytotoxicity Screening

• Cytotoxicity screening factsheet Admescope

Cardiotoxicity Screening

• hERG screening factsheet Admescope

Biologics

ADC Characterization

• ADC characterization factsheet Admescope

Quantification with LC-MS

• Targeted protein quantification factsheet Admescope

Quantification with ELISA

• ELISA quantification factsheet Admescope

Protein MW and Structural Characterization (LC-MS)

• Protein MW characterization factsheet Admescope

Peptide Mapping

• Peptide mapping factsheet Admescope

Released N-glycan Profiling

Biomolecular Interactions

• Biomolecular interactions factsheet Admescope