Factsheets

In vitro Metabolism

Metabolic Stability

• Admescope Metabolic stability factsheet
• Admescope Low clearance metabolism factsheet

Metabolite Identification and Profiling

• Admescope Metabolite identification factsheet
• Admescope Peptide metabolite identification factsheet

Enzyme Reaction Phenotyping

• Admescope CYP phenotyping factsheet
• Admescope UGT phenotyping factsheet
• Admescope Low clearance CYP phenotyping factsheet

Reactive Metabolite Screening

• Admescope Reactive metabolites factsheet
• Admescope Covalent binding factsheet

Acyl-Glucuronide Reactivity

• Admescope Acyl glucuronide reactivity factsheet

Safety Metabolism

• Admescope MIST analysis factsheet
• Admescope Radiolabeled in vivo metabolite ID and profiling factsheet

In vivo DMPK

• Admescope PKscreen factsheet
• Admescope PKlead factsheet
• Admescope Metabolite ID in vivo factsheet

Drug Interactions

CYP Inhibition

• Admescope Inhibmics factsheet
• Admescope TDIprofile factsheet
• Admescope Inhibprofile factsheet

UGT Inhibition

• Admescope UGTinhibition factsheet

CYP Induction

• Admescope Inductprofile factsheet
• Admescope Inductscreen factsheet
• Admescope PXRscreen factsheet

UGT Induction

• Admescope UGTinhibition factsheet

Permeability and Transporters

Caco-2 / MDCK Permeability factsheets

• Admescope Cacoscreen factsheet
• Admescope Cacoprofile factsheet

Efflux transporters

• Admescope Effluxinhib factsheet
• Admescope Effluxsubst factsheet
• Admescope Effluxinhib vesicle factsheet

Uptake Transporters

• Admescope Uptakesubst factsheet
• Admescope Uptakeinhib factsheet

Physicochemistry and Binding

Lipophilicity (logP/D)

• Admescope LogD factsheet
• Admescope Elogscreen factsheet

Solubility

• Admescope Solubility factsheet

Plasma Protein Binding

• Admescope Protein Binding UF factsheet
• Admescope Protein binding RED factsheet

Red Blood Cell Binding

• Admescope Red Blood-cell-binding factsheet

In vitro Toxicology

Hepatotoxicity Screening

• Admescope Cytotoxicity and cell stress fact sheet
• Admescope Lysosomal trapping fact sheet
• Admescope Steatosis and phospholipidosis fact sheet

Cardiotoxicity Screening

• Admescope hERGscreen factsheet

Genotoxicity Screening

• Admescope MiniAMES factsheet
• Admescope MNTscreen factsheet

Cytotoxicity Screening

• Admescope Cytoxscreen factsheet

Biologics

• Admescope Protein MW characterisation factsheet

• Admescope Peptide-mapping factsheet

• Admescope Released-N-glycan profiling factsheet

• Admescope Targeted protein quantification factsheet

• Admescope ELISA quantification factsheet

• Admescope PKscreen factsheet
• Admescope PKlead factsheet

• Admescope Biomolecular interactions factsheet

• Admescope ADC characterization factsheet